breast cancer biomarker discovery: proteomics and genomics approaches

نویسندگان

akram safaei

mostafa rezaei-tavirani

sara sobhi

mohammad esmaeil akbari

چکیده

abstract breast cancer is one of the major health problems of the eastern world. regardless of the survival rate improvement with progression in screening and adjuvant systemic therapies, still one – third of the patients with primary breast cancer have recurrence of micro metastasis after 10 years.  it is important to discover a reliable biomarker for detection of breast cancer. the underlying molecular mechanism of the disease needs to be better understood. allied to genomics, proteomics technologies promise to be valuable for identifying new markers that improve screening, early diagnosis, prognosis and prediction of therapeutic response or toxicity, as well as the identification of new therapeutic targets. in this review, we present proteomic and genomic sciences have been used for differential analysis of breast cancer to find molecular changes of cancer for detection candidate biomarkers.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Proteomics for Cancer Biomarker Discovery

Background: If we are to successfully treat cancer, we must understand the biologic underpinnings in conjunction with early diagnosis. Genome-wide expression studies have advanced the research of many cancers. Nevertheless, understanding which genes are expressed in a tumor is not equivalent to knowing which proteins are being produced. Proteomics hold great promise for careful examination of t...

متن کامل

Proteomics for cancer biomarker discovery.

The emergence of novel technologies allows researchers to facilitate the comprehensive analyses of genomes, transcriptomes, and proteomes in health and disease. The information that is expected from such technologies may soon exert a dramatic change in the pace of cancer research and impact dramatically on the care of cancer patients. These approaches have already demonstrated the power of mole...

متن کامل

An Integrative Genomics Approach to Biomarker Discovery in Breast Cancer

Genome-wide association studies (GWAS) have successfully identified genetic variants associated with risk for breast cancer. However, the molecular mechanisms through which the identified variants confer risk or influence phenotypic expression remains poorly understood. Here, we present a novel integrative genomics approach that combines GWAS information with gene expression data to assess the ...

متن کامل

Proteomics in Biomarker Discovery for Prostate Cancer

The use of prostate specific antigen (PSA)-based screening of prostate cancer (PCa) results with overdiagnosis of the disease, unnecessary biopsies and high medical cost treatments. The discovery of new biomarkers in blood, urine or tissue that will permit early detection and treatment of patients with aggressive disease and, concomitantly, avoid overtreatment for low risk cases are urgently ne...

متن کامل

Salivary proteomics for oral cancer biomarker discovery.

PURPOSE This study aims to explore the presence of informative protein biomarkers in the human saliva proteome and to evaluate their potential for detection of oral squamous cell carcinoma (OSCC). EXPERIMENTAL DESIGN Whole saliva samples were collected from patients (n = 64) with OSCC and matched healthy subjects (n = 64). The proteins in pooled whole saliva samples of patients with OSCC (n =...

متن کامل

The network biomarker discovery in prostate cancer from both genomics and proteomics levels

Both mass spectrometry (MS) and microarray technologies are very promising for discovery of new biomarkers for clinical diagnosis. In order to identify the high-confidence biomarkers from expression datasets, we proposed a new pipeline for biomarker discovery, in which the disease information of proteins/genes, different levels of expression profiles (microarray datasets and proteomics datasets...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of cancer prevention

جلد ۶، شماره ۰۳، صفحات ۴۵-۵۳

کلمات کلیدی
[ ' b r e a s t c a n c e r ' , ' b i o l o g i c a l m a r k e r s ' , ' p r o t e o m i c s ' , ' g e n o m i c s 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 d r a k e r r ' , ' c a z a r e s l h ' , ' j o n e s e e ' , ' f u l l e r t w ' , ' s e m m e s o j ' , ' l a r o n g a c . c h a l l e n g e s t o d e v e l o p i n g p r o t e o m i c ' , ' b a s e d b r e a s t c a n c e r d i a g n o s t i c s . o m i c s ' , ' a j o u r n a l o f i n t e g r a t i v e b i o l o g y . 2 0 1 1 ' , ' 1 5 ( 5 ) ' , 2 5 1 , ' 9 . 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 u g n a t a ' , ' x i e l ' , ' m o r r i s s j ' , ' s e m e n c i w r ' , ' m a o y . s u r v i v a l o f w o m e n w i t h b r e a s t c a n c e r i n o t t a w a ' , ' c a n a d a ' , ' v a r i a t i o n w i t h a g e ' , ' s t a g e ' , ' h i s t o l o g y ' , ' g r a d e a n d t r e a t m e n t . b r i t i s h j o u r n a l o f c a n c e r . 2 0 0 4 ' , ' 9 0 ( 6 ) ' , 1 1 3 8 , ' 4 3 . 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l i c i . d i s c o v e r y a n d v a l i d a t i o n o f b r e a s t c a n c e r e a r l y d e t e c t i o n b i o m a r k e r s i n p r e c l i n i c a l s a m p l e s . h o r m o n e s a n d c a n c e r . 2 0 1 1 ' , ' 2 ( 2 ) ' , 1 2 5 , ' 3 1 . 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 i s s a q h j ' , ' b l o n d e r j . e l e c t r o p h o r e s i s a n d l i q u i d c h r o m a t o g r a p h y / t a n d e m m a s s s p e c t r o m e t r y i n d i s e a s e b i o m a r k e r d i s c o v e r y . j o u r n a l o f c h r o m a t o g r a p h y b . 2 0 0 9 ' , ' 8 7 7 ( 1 3 ) ' , 1 2 2 2 , ' 8 . 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k u m a r s ' , ' m o h a n a ' , ' g u l e r i a r . b i o m a r k e r s i n c a n c e r s c r e e n i n g ' , ' r e s e a r c h a n d d e t e c t i o n ' , ' p r e s e n t a n d f u t u r e ' , ' a r e v i e w . b i o m a r k e r s . 2 0 0 6 ' , ' 1 1 ( 5 ) ' , 3 8 5 , ' 4 0 5 . 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 c h e a n g m c u ' , ' v a n d e r i j n m ' , ' n i e l s e n t o . g e n e e x p r e s s i o n p r o f i l i n g o f b r e a s t c a n c e r . a n n u r e v p a t h m e c h d i s m e c h d i s . 2 0 0 8 ' , 3 , 6 7 , ' 9 7 . 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m o r r i s s r ' , ' c a r e y l a . g e n e e x p r e s s i o n p r o f i l i n g i n b r e a s t c a n c e r . c u r r e n t o p i n i o n i n o n c o l o g y . 2 0 0 7 ' , ' 1 9 ( 6 ) ' , ' 5 4 7 . 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s o t i r i o u c ' , ' p u s z t a i l . g e n e ' , ' e x p r e s s i o n s i g n a t u r e s i n b r e a s t c a n c e r . n e w e n g l a n d j o u r n a l o f m e d i c i n e . 2 0 0 9 ' , ' 3 6 0 ( 8 ) ' , 7 9 0 , ' 8 0 0 . 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k i m s y ' , ' h a h n w c . c a n c e r g e n o m i c s ' , ' i n t e g r a t i n g f o r m a n d f u n c t i o n . c a r c i n o g e n e s i s . 2 0 0 7 ' , ' 2 8 ( 7 ) ' , 1 3 8 7 , ' 9 2 . 1 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 g a s t m c w ' , ' s c h e l l e n s j h m ' , ' b e i j n e n j h . c l i n i c a l p r o t e o m i c s i n b r e a s t c a n c e r ' , ' a r e v i e w . b r e a s t c a n c e r r e s e a r c h a n d t r e a t m e n t . 2 0 0 9 ' , ' 1 1 6 ( 1 ) ' , 1 7 , ' 2 9 . 1 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 d a v i s m ' , ' h a n a s h s . h i g h ' , ' t h r o u g h p u t g e n o m i c t e c h n o l o g y i n r e s e a r c h a n d c l i n i c a l m a n a g e m e n t o f b r e a s t c a n c e r . p l a s m a ' , ' b a s e d p r o t e o m i c s i n e a r l y d e t e c t i o n a n d t h e r a p y . b r e a s t c a n c e r r e s e a r c h . 2 0 0 6 ' , ' 8 ( 6 ) ' , ' 2 1 7 . 1 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 d r u k i e r a k ' , ' o s s e t r o v a n ' , ' s c h o r s e ' , ' k r a s i k g ' , ' g r i g o r i e v i ' , ' k o e n i g c ' , ' e t a l . h i g h ' , ' s e n s i t i v i t y b l o o d ' , ' b a s e d d e t e c t i o n o f b r e a s t c a n c e r b y m u l t i p h o t o n d e t e c t i o n d i a g n o s t i c p r o t e o m i c s . j o u r n a l o f p r o t e o m e r e s e a r c h . 2 0 0 6 ' , ' 5 ( 8 ) ' , 1 9 0 6 , ' 1 5 . 1 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 a n d e r s o n k s ' , ' r a m a c h a n d r a n n ' , ' w o n g j ' , ' r a p h a e l j v ' , ' h a i n s w o r t h e ' , ' d e m i r k a n g ' , ' e t a l . a p p l i c a t i o n o f p r o t e i n m i c r o a r r a y s f o r m u l t i p l e x e d d e t e c t i o n o f a n t i b o d i e s t o t u m o r a n t i g e n s i n b r e a s t c a n c e r . j o u r n a l o f p r o t e o m e r e s e a r c h . 2 0 0 8 ' , ' 7 ( 4 ) ' , 1 4 9 0 , ' 9 . 1 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l ö n n e b o r g a ' , ' a a r ø e j ' , ' d u m e a u x v ' , ' b ø r r e s e n ' , ' d a l e a l . f o u n d i n t r a n s c r i p t i o n ' , ' g e n e e x p r e s s i o n a n d o t h e r n o v e l b l o o d b i o m a r k e r s f o r t h e e a r l y d e t e c t i o n o f b r e a s t c a n c e r . e x p e r t r e v i e w o f a n t i c a n c e r t h e r a p y . 2 0 0 9 ' , ' 9 ( 8 ) ' , 1 1 1 5 , ' 2 3 . 1 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 b r o w n n m ' , ' s t e n z e l t t ' , ' f r i e d m a n p n ' , ' h e n s l e e j ' , ' h u p e r g ' , ' m a r k s j r . e v a l u a t i o n o f e x p r e s s i o n b a s e d m a r k e r s f o r t h e d e t e c t i o n o f b r e a s t c a n c e r c e l l s . b r e a s t c a n c e r r e s e a r c h a n d t r e a t m e n t . 2 0 0 6 ' , ' 9 7 ( 1 ) ' , 4 1 , ' 7 . 1 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 a l e s s a n d r o g ' , ' m i c h e l e i ' , ' p a r i d e p ' , ' n a m s h i n k ' , ' g i u l i a s ' , ' l a r r y c ' , ' e t a l . a t r a n s c r i p t i o n a l s k e t c h o f a p r i m a r y h u m a n b r e a s t c a n c e r b y 4 5 4 d e e p s e q u e n c i n g . b m c g e n o m i c s . 2 0 0 9 ' , ' 1 0 . 1 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 a a r o e j ' , ' l i n d a h l t ' , ' d u m e a u x v ' , ' s a e b o s ' , ' t o b i n d ' , ' h a g e n n ' , ' e t a l . g e n e e x p r e s s i o n p r o f i l i n g o f p e r i p h e r a l b l o o d c e l l s f o r e a r l y d e t e c t i o n o f b r e a s t c a n c e r . b r e a s t c a n c e r r e s . 2 0 1 0 ' , ' 1 2 ( 1 ) ' , ' r 7 . 1 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m e l n i k o v a a ' , ' s c h o l t e n s d m ' , ' w i l e y e l ' , ' k h a n s a ' , ' l e v e n s o n v v . a r r a y ' , ' b a s e d m u l t i p l e x a n a l y s i s o f d n a m e t h y l a t i o n i n b r e a s t c a n c e r t i s s u e s . t h e j o u r n a l o f m o l e c u l a r d i a g n o s t i c s ' , ' j m d . 2 0 0 8 ' , ' 1 0 ( 1 ) ' , ' 9 3 . 1 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a r t e n s j w m ' , ' m a r g o s s i a n a l ' , ' s c h m i t t m ' , ' f o e k e n s j ' , ' h a r b e c k n . d n a m e t h y l a t i o n a s a b i o m a r k e r i n b r e a s t c a n c e r . f u t u r e o n c o l o g y . 2 0 0 9 ' , ' 5 ( 8 ) ' , 1 2 4 5 , ' 5 6 . 2 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 g r o g a n r h ' , ' m i t m a k e r e j ' , ' c l a r k o h . t h e e v o l u t i o n o f b i o m a r k e r s i n t h y r o i d c a n c e r f r o m m a s s s c r e e n i n g t o a p e r s o n a l i z e d b i o s i g n a t u r e . c a n c e r s . 2 0 1 0 ' , ' 2 ( 2 ) ' , 8 8 5 , ' 9 1 2 . 2 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 h o h e i s e l j d . m i c r o a r r a y t e c h n o l o g y ' , ' b e y o n d t r a n s c r i p t p r o f i l i n g a n d g e n o t y p e a n a l y s i s . n a t u r e r e v i e w s g e n e t i c s . 2 0 0 6 ' , ' 7 ( 3 ) ' , 2 0 0 , ' 1 0 . 2 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 e l l s w o r t h d l ' , ' e l l s w o r t h r e ' , ' l i e b m a n m n ' , ' h o o k e j a ' , ' s h r i v e r c d . g e n o m i c i n s t a b i l i t y i n h i s t o l o g i c a l l y n o r m a l b r e a s t t i s s u e s ' , ' i m p l i c a t i o n s f o r c a r c i n o g e n e s i s . t h e l a n c e t o n c o l o g y . 2 0 0 4 ' , ' 5 ( 1 2 ) ' , 7 5 3 , ' 8 . 2 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 z h a n g b ' , ' b e e g h l y ' , ' f a d i e l a ' , ' l o n g j ' , ' z h e n g w . g e n e t i c v a r i a n t s a s s o c i a t e d w i t h b r e a s t ' , ' c a n c e r r i s k ' , ' c o m p r e h e n s i v e r e s e a r c h s y n o p s i s ' , ' m e t a ' , ' a n a l y s i s ' , ' a n d e p i d e m i o l o g i c a l e v i d e n c e . t h e l a n c e t o n c o l o g y . 2 0 1 1 ' , ' 1 2 ( 5 ) ' , 4 7 7 , ' 8 8 . 2 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 y u k d ' , ' d i g h ' , ' f a n l ' , ' c h e n a x ' , ' y a n g c ' , ' s h a o z m . l a c k o f a n a s s o c i a t i o n b e t w e e n a f u n c t i o n a l p o l y m o r p h i s m i n t h e i n t e r l e u k i n ' , ' 6 g e n e p r o m o t e r a n d b r e a s t c a n c e r r i s k ' , ' a m e t a ' , ' a n a l y s i s i n v o l v i n g 2 5 ' , ' 7 0 3 s u b j e c t s . b r e a s t c a n c e r r e s e a r c h a n d t r e a t m e n t . 2 0 1 0 ' , ' 1 2 2 ( 2 ) ' , 4 8 3 , ' 8 . 2 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 a y o u b n ' , ' l u c a s c ' , ' k a d d o u m i a . g e n o m i c s a n d p h a r m a c o g e n o m i c s o f b r e a s t c a n c e r ' , ' c u r r e n t k n o w l e d g e a n d t r e n d s . a s i a n p a c i f i c j o u r n a l o f c a n c e r p r e v e n t i o n . 2 0 1 1 ' , 1 2 , 1 1 2 7 , ' 4 0 . 2 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 c h e r b a l f ' , ' s a l h i n ' , ' b a k o u r r ' , ' a d a n e s ' , ' b o u a l g a k ' , ' m a i l l e t p . b r c a 1 a n d b r c a 2 u n c l a s s i f i e d v a r i a n t s a n d m i s s e n s e p o l y m o r p h i s m s i n a l g e r i a n b r e a s t / o v a r i a n c a n c e r f a m i l i e s . d i s e a s e m a r k e r s . 2 0 1 2 ' , ' 3 2 ( 6 ) ' , 3 4 3 , ' 5 3 . 2 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a c h a c k o v a e ' , ' f o r e t o v a l ' , ' l u k e s o v a m ' , ' v a s i c k o v a p ' , ' n a v r a t i l o v a m ' , ' c o e n e i ' , ' e t a l . s p e c t r u m a n d c h a r a c t e r i s a t i o n o f b r c a 1 a n d b r c a 2 d e l e t e r i o u s m u t a t i o n s i n h i g h ' , ' r i s k c z e c h p a t i e n t s w i t h b r e a s t a n d / o r o v a r i a n c a n c e r . b m c c a n c e r . 2 0 0 8 ' , ' 8 ( 1 ) ' , ' 1 4 0 . 2 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s e a l s ' , ' t h o m p s o n d ' , ' r e n w i c k a ' , ' e l l i o t t a ' , ' k e l l y p ' , ' b a r f o o t r ' , ' e t a l . t r u n c a t i n g m u t a t i o n s i n t h e f a n c o n i a n e m i a j g e n e b r i p 1 a r e l o w ' , ' p e n e t r a n c e b r e a s t c a n c e r s u s c e p t i b i l i t y a l l e l e s . n a t u r e g e n e t i c s . 2 0 0 6 ' , ' 3 8 ( 1 1 ) ' , 1 2 3 9 , ' 4 1 . 2 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 w e i s c h e r m ' , ' b o j e s e n s e ' , ' t y b j æ r g ' , ' h a n s e n a ' , ' a x e l s s o n c k ' , ' n o r d e s t g a a r d b g . i n c r e a s e d r i s k o f b r e a s t c a n c e r a s s o c i a t e d w i t h c h e k 2 * 1 1 0 0 d e l c . j o u r n a l o f c l i n i c a l o n c o l o g y . 2 0 0 7 ' , ' 2 5 ( 1 ) ' , 5 7 , ' 6 3 . 3 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 f i t z g e r a l d m g ' , ' m a c d o n a l d d j ' , ' k r a i n e r m ' , ' h o o v e r i ' , ' o & ' , ' # 0 3 9 ' , ' n e i l e ' , ' u n s a l h ' , ' e t a l . g e r m ' , ' l i n e b r c a 1 m u t a t i o n s i n j e w i s h a n d n o n ' , ' j e w i s h w o m e n w i t h e a r l y ' , ' o n s e t b r e a s t c a n c e r . n e w e n g l a n d j o u r n a l o f m e d i c i n e . 1 9 9 6 ' , ' 3 3 4 ( 3 ) ' , 1 4 3 , ' 9 . 3 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a s c i a r i s ' , ' d i l l o n d a ' , ' r a t h m ' , ' r o b s o n m ' , ' w e i t z e l j n ' , ' b a l m a n a j ' , ' e t a l . b r e a s t c a n c e r p h e n o t y p e i n w o m e n w i t h t p 5 3 g e r m l i n e m u t a t i o n s ' , ' a l i ' , ' f r a u m e n i s y n d r o m e c o n s o r t i u m e f f o r t . b r e a s t c a n c e r r e s e a r c h a n d t r e a t m e n t . 2 0 1 2 ' , ' 1 3 3 ( 3 ) ' , 1 1 2 5 , ' 3 0 . 3 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 h u d e l i s t g ' , ' s i n g e r c f ' , ' p i s c h i n g e r k i d ' , ' k a s e r e r k ' , ' m a n a v i m ' , ' k u b i s t a e ' , ' e t a l . p r o t e o m i c a n a l y s i s i n h u m a n b r e a s t c a n c e r ' , ' i d e n t i f i c a t i o n o f a c h a r a c t e r i s t i c p r o t e i n e x p r e s s i o n p r o f i l e o f m a l i g n a n t b r e a s t e p i t h e l i u m . p r o t e o m i c s . 2 0 0 6 ' , ' 6 ( 6 ) ' , 1 9 8 9 , ' 2 0 0 2 . 3 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 h a b e r m a n n j k ' , ' d o e r i n g j ' , ' h a u t a n i e m i s ' , ' r o b l i c k u j ' , ' b ü n d g e n n k ' , ' n i c o r i c i d ' , ' e t a l . t h e g e n e e x p r e s s i o n s i g n a t u r e o f g e n o m i c i n s t a b i l i t y i n b r e a s t c a n c e r i s a n i n d e p e n d e n t p r e d i c t o r o f c l i n i c a l o u t c o m e . i n t e r n a t i o n a l j o u r n a l o f c a n c e r . 2 0 0 9 ' , ' 1 2 4 ( 7 ) ' , 1 5 5 2 , ' 6 4 . 3 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k w e i k a ' , ' k u n g y ' , ' s a l a r i k ' , ' h o l c o m b i n ' , ' p o l l a c k j r . g e n o m i c i n s t a b i l i t y i n b r e a s t c a n c e r ' , ' p a t h o g e n e s i s a n d c l i n i c a l i m p l i c a t i o n s . m o l e c u l a r o n c o l o g y . 2 0 1 0 ' , ' 4 ( 3 ) ' , 2 5 5 , ' 6 6 . 3 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 c h i s t i a k o v d a ' , ' h e l l e m a n s b ' , ' v o l c k a e r t f a m . m i c r o s a t e l l i t e s a n d t h e i r g e n o m i c d i s t r i b u t i o n ' , ' e v o l u t i o n ' , ' f u n c t i o n a n d a p p l i c a t i o n s ' , ' a r e v i e w w i t h s p e c i a l r e f e r e n c e t o f i s h g e n e t i c s . a q u a c u l t u r e . 2 0 0 6 ' , ' 2 5 5 ( 1 ) ' , 1 , ' 2 9 . 3 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 j a n a t o v a m ' , ' p o h l r e i c h p . m i c r o s a t e l l i t e m a r k e r s i n b r e a s t c a n c e r s t u d i e s . p r a g u e m e d i c a l r e p o r t . 2 0 0 4 ' , ' 1 0 5 ( 2 ) ' , 1 1 1 , ' 8 . 3 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s i a h s p ' , ' q u i n n d m ' , ' b e n n e t t g d ' , ' c a s e y g ' , ' f l o w e r r l p ' , ' s u t h e r s g ' , ' e t a l . m i c r o s a t e l l i t e i n s t a b i l i t y m a r k e r s i n b r e a s t c a n c e r ' , ' a r e v i e w a n d s t u d y s h o w i n g m s i w a s n o t d e t e c t e d a t b a t 2 5 a n d b a t 2 6 m i c r o s a t e l l i t e m a r k e r s i n e a r l y ' , ' o n s e t b r e a s t c a n c e r . b r e a s t c a n c e r r e s e a r c h a n d t r e a t m e n t . 2 0 0 0 ' , ' 6 0 ( 2 ) ' , 1 3 5 , ' 4 2 . 3 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 o k a d a s ' , ' t o k u n a g a e ' , ' k i t a o h ' , ' a k i y o s h i s ' , ' y a m a s h i t a n ' , ' s a e k i h ' , ' e t a l . l o s s o f h e t e r o z y g o s i t y a t b r c a 1 l o c u s i s s i g n i f i c a n t l y a s s o c i a t e d w i t h a g g r e s s i v e n e s s a n d p o o r p r o g n o s i s i n b r e a s t c a n c e r . a n n a l s o f s u r g i c a l o n c o l o g y . 2 0 1 2 ' , 1 , ' 9 . 3 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 c a l l a h a n r ' , ' c r o p p c ' , ' m e r l o g r ' , ' d i e l l a f ' , ' v e n e s i o t ' , ' l i d e r e a u r ' , ' e t a l . g e n e t i c a n d m o l e c u l a r h e t e r o g e n e i t y o f b r e a s t c a n c e r c e l l s . c l i n i c a c h i m i c a a c t a . 1 9 9 3 ' , ' 2 1 7 ( 1 ) ' , 6 3 , ' 7 3 . 4 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 n o w a c k a ' , ' z a w i s z a m ' , ' b r y ś m ' , ' r o m a n o w i c z ' , ' m a k o w s k a h ' , ' k u l i g a ' , ' k r a j e w s k a w m . g e n e t i c i n s t a b i l i t y i n t h e r a d 5 1 a n d b r c a 1 r e g i o n s i n b r e a s t c a n c e r . c e l l u l a r & ' , ' m o l e c u l a r b i o l o g y l e t t e r s . 2 0 0 7 ' , ' 1 2 ( 2 ) ' , 1 9 2 , ' 2 0 5 . 4 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s i l v a s o a r e s e w ' , ' d e l i m a s a n t o s s c ' , ' b u e n o a g ' , ' c a v a l l i i j ' , ' c a v a l l i l r ' , ' f o u t o m a t i a s j e ' , ' e t a l . c o n c o m i t a n t l o s s o f h e t e r o z y g o s i t y a t t h e & ' , ' l t ' , ' i & ' , ' g t ' , ' b r c a 1 & ' , ' l t ' , ' / i & ' , ' g t ' , ' a n d & ' , ' l t ' , ' i & ' , ' g t ' , ' f h i t & ' , ' l t ' , ' / i & ' , ' g t ' , ' g e n e s a s a p r o g n o s t i c f a c t o r i n s p o r a d i c b r e a s t c a n c e r . c a n c e r g e n e t i c s a n d c y t o g e n e t i c s . 2 0 1 0 ' , ' 1 9 9 ( 1 ) ' , 2 4 , ' 3 0 . 4 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 r o n c u z z i l ' , ' b r o g n a r a i ' , ' b a i o c c h i d ' , ' a m a d o r i d ' , ' g a s p e r i ' , ' c a m p a n i a . l o s s o f h e t e r o z y g o s i t y a t 1 7 p 1 3 . 3 ' , ' t e r ' , ' d i s t a l t o t p 5 3 ' , ' c o r r e l a t e s w i t h n e g a t i v e h o r m o n a l p h e n o t y p e i n s p o r a d i c b r e a s t c a n c e r . o n c o l o g y r e p o r t s . 2 0 0 5 ' , ' 1 4 ( 2 ) ' , 4 7 1 , ' 4 . 4 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 c l e t o n ' , ' j a n s e n a m . e ' , ' c a d h e r i n a n d l o s s o f h e t e r o z y g o s i t y a t c h r o m o s o m e 1 6 i n b r e a s t c a r c i n o g e n e s i s ' , ' d i f f e r e n t g e n e t i c p a t h w a y s i n d u c t a l a n d l o b u l a r b r e a s t c a n c e r ? b r e a s t c a n c e r r e s e a r c h . 2 0 0 2 ' , ' 4 ( 1 ) ' , 5 , ' 8 . 4 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 p a n d i s n ' , ' b a r d i g ' , ' m i t e l m a n f ' , ' h e l m s . d e l e t i o n o f t h e s h o r t a r m o f c h r o m o s o m e 3 i n b r e a s t t u m o r s . g e n e s ' , ' c h r o m o s o m e s a n d c a n c e r . 1 9 9 7 ' , ' 1 8 ( 4 ) ' , 2 4 1 , ' 5 . 4 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 t o k u n a g a e ' , ' o k a d a s ' , ' y a m a s h i t a n ' , ' a k i y o s h i s ' , ' k i t a o h ' , ' m o r i t a m ' , ' e t a l . h i g h i n c i d e n c e a n d f r e q u e n c y o f l o h a r e a s s o c i a t e d w i t h a g g r e s s i v e f e a t u r e s o f h i g h ' , ' g r a d e h e r 2 a n d t r i p l e ' , ' n e g a t i v e b r e a s t c a n c e r s . b r e a s t c a n c e r . 2 0 1 2 ' , 1 , ' 9 . 4 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 n o w a c k a ' , ' z a w i s z a m ' , ' b r y s m ' , ' r o m a n o w i c z ' , ' m a k o w s k a h ' , ' z a d r o z n y m ' , ' k u l i g a ' , ' k r a j e w s k a w m . l o s s o f h e t e r o z y g o s i t y a n d m i c r o s a t e l l i t e i n s t a b i l i t y a t r a d 5 2 a n d r a d 5 4 l o c i i n b r e a s t c a n c e r . p o l i s h j o u r n a l o f p a t h o l o g y . 2 0 0 6 ' , ' 5 7 ( 2 ) ' , 8 3 , ' 9 . 4 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 c h e u n g a ' , ' d e n g w . t e l o m e r e d y s f u n c t i o n ' , ' g e n o m e i n s t a b i l i t y a n d c a n c e r . f r o n t i e r s i n b i o s c i e n c e ' , ' a j o u r n a l a n d v i r t u a l l i b r a r y . 2 0 0 8 ' , 1 3 , ' 2 0 7 5 . 4 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 f u k i n o k ' , ' s h e n l ' , ' p a t o c s a ' , ' m u t t e r g l ' , ' e n g c . g e n o m i c i n s t a b i l i t y w i t h i n t u m o r s t r o m a a n d c l i n i c o p a t h o l o g i c a l c h a r a c t e r i s t i c s o f s p o r a d i c p r i m a r y i n v a s i v e b r e a s t c a r c i n o m a . j a m a ' , ' t h e j o u r n a l o f t h e a m e r i c a n m e d i c a l a s s o c i a t i o n . 2 0 0 7 ' , ' 2 9 7 ( 1 9 ) ' , 2 1 0 3 , ' 1 1 . 4 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a r t i n e z ' , ' d e l g a d o b ' , ' y a n o w s k y k ' , ' i n g l a d a ' , ' p e r e z l ' , ' d e l a h o y a m ' , ' c a l d e s t ' , ' v e g a a ' , ' e t a l . s h o r t e r t e l o m e r e l e n g t h i s a s s o c i a t e d w i t h i n c r e a s e d o v a r i a n c a n c e r r i s k i n b o t h f a m i l i a l a n d s p o r a d i c c a s e s . j o u r n a l o f m e d i c a l g e n e t i c s . 2 0 1 2 ' , ' 4 9 ( 5 ) ' , 3 4 1 , ' 4 . 5 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 g r i f f i t h j k ' , ' b r y a n t j e ' , ' f o r d y c e c a ' , ' g i l l i l a n d f d ' , ' j o s t e n e ' , ' m o y z i s r k . r e d u c e d t e l o m e r e d n a c o n t e n t i s c o r r e l a t e d w i t h g e n o m i c i n s t a b i l i t y a n d m e t a s t a s i s i n i n v a s i v e h u m a n b r e a s t c a r c i n o m a . b r e a s t c a n c e r r e s e a r c h a n d t r e a t m e n t . 1 9 9 9 ' , ' 5 4 ( 1 ) ' , 5 9 , ' 6 4 . 5 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 z h e n g y l ' , ' z h o u x ' , ' l o f f r e d o c a ' , ' s h i e l d s p g ' , ' s u n b . t e l o m e r e d e f i c i e n c i e s o n c h r o m o s o m e s 9 p ' , ' 1 5 p ' , ' 1 5 q a n d x p ' , ' p o t e n t i a l b i o m a r k e r s f o r b r e a s t c a n c e r r i s k . h u m a n m o l e c u l a r g e n e t i c s . 2 0 1 1 ' , ' 2 0 ( 2 ) ' , 3 7 8 , ' 8 6 . 5 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a r t i n e z ' , ' d e l g a d o b ' , ' y a n o w s k y k ' , ' i n g l a d a ' , ' p e r e z l ' , ' d o m i n g o s ' , ' u r i o s t e m ' , ' o s o r i o a ' , ' e t a l . g e n e t i c a n t i c i p a t i o n i s a s s o c i a t e d w i t h t e l o m e r e s h o r t e n i n g i n h e r e d i t a r y b r e a s t c a n c e r . p l o s g e n e t i c s . 2 0 1 1 ' , ' 7 ( 7 ) ' , ' e 1 0 0 2 1 8 2 . 5 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m e e k e r a k ' , ' a r g a n i p . t e l o m e r e s h o r t e n i n g o c c u r s e a r l y d u r i n g b r e a s t t u m o r i g e n e s i s ' , ' a c a u s e o f c h r o m o s o m e d e s t a b i l i z a t i o n u n d e r l y i n g m a l i g n a n t t r a n s f o r m a t i o n ? j o u r n a l o f m a m m a r y g l a n d b i o l o g y a n d n e o p l a s i a . 2 0 0 4 ' , ' 9 ( 3 ) ' , 2 8 5 , ' 9 6 . 5 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 b i s o f f i m ' , ' h e a p h y c m ' , ' g r i f f i t h j k . t e l o m e r e s ' , ' p r o g n o s t i c m a r k e r s f o r s o l i d t u m o r s . i n t e r n a t i o n a l j o u r n a l o f c a n c e r . 2 0 0 6 ' , ' 1 1 9 ( 1 0 ) ' , 2 2 5 5 , ' 6 0 . 5 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 b r o o k s j d ' , ' c a i r n s p ' , ' s h o r e r e ' , ' k l e i n c b ' , ' w i r g i n i ' , ' a f a n a s y e v a y ' , ' e t a l . d n a m e t h y l a t i o n i n p r e ' , ' d i a g n o s t i c s e r u m s a m p l e s o f b r e a s t c a n c e r c a s e s ' , ' r e s u l t s o f a n e s t e d c a s e c o n t r o l s t u d y . c a n c e r e p i d e m i o l o g y . 2 0 1 0 ' , ' 3 4 ( 6 ) ' , 7 1 7 , ' 2 3 . 5 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 h u a n g y ' , ' n a y a k s ' , ' j a n k o w i t z r ' , ' d a v i d s o n n e ' , ' o e s t e r r e i c h s . e p i g e n e t i c s i n b r e a s t c a n c e r ' , ' w h a t s n e w . b r e a s t c a n c e r r e s . 2 0 1 1 ' , ' 1 3 ( 6 ) ' , ' 2 2 5 . 5 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s h a r m a s ' , ' k e l l y t k ' , ' j o n e s p a . e p i g e n e t i c s i n c a n c e r . c a r c i n o g e n e s i s . 2 0 1 0 ' , ' 3 1 ( 1 ) ' , 2 7 , ' 3 6 . 5 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s u i j k e r b u i j k k ' , ' v a n d i e s t p ' , ' v a n d e r w a l l e . i m p r o v i n g e a r l y b r e a s t c a n c e r d e t e c t i o n ' , ' f o c u s o n m e t h y l a t i o n . a n n a l s o f o n c o l o g y . 2 0 1 1 ' , ' 2 2 ( 1 ) ' , 2 4 , ' 9 . 5 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 d u m i t r e s c u r g . e p i g e n e t i c m a r k e r s o f e a r l y t u m o r d e v e l o p m e n t . m e t h o d s i n m o l e c u l a r b i o l o g y ( c l i f t o n ' , ' n j ) . 2 0 1 2 ' , 8 6 3 , ' 3 . 6 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 w a n g w ' , ' s r i v a s t a v a s . s t r a t e g i c a p p r o a c h t o v a l i d a t i n g m e t h y l a t e d g e n e s a s b i o m a r k e r s f o r b r e a s t c a n c e r . c a n c e r p r e v e n t i o n r e s e a r c h . 2 0 1 0 ' , ' 3 ( 1 ) ' , 1 6 , ' 2 4 . 6 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 o r d w a y j m ' , ' b u d i m a n m a ' , ' k o r s h u n o v a y ' , ' m a l o n e y r k ' , ' b e d e l l j a ' , ' c i t e k r w ' , ' e t a l . i d e n t i f i c a t i o n o f n o v e l h i g h ' , ' f r e q u e n c y d n a m e t h y l a t i o n c h a n g e s i n b r e a s t c a n c e r . p l o s o n e . 2 0 0 7 ' , ' 2 ( 1 2 ) ' , ' e 1 3 1 4 . 6 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 t o m m a s i s ' , ' k a r m d l ' , ' w u x ' , ' y e n y ' , ' p f e i f e r g p . m e t h y l a t i o n o f h o m e o b o x g e n e s i s a f r e q u e n t a n d e a r l y e p i g e n e t i c e v e n t i n b r e a s t c a n c e r . b r e a s t c a n c e r r e s . 2 0 0 9 ' , ' 1 1 ( 1 ) ' , ' r 1 4 . 6 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 t i n g a h ' , ' m c g a r v e y k m ' , ' b a y l i n s b . t h e c a n c e r e p i g e n o m e c o m p o n e n t s a n d f u n c t i o n a l c o r r e l a t e s . g e n e s & ' , ' d e v e l o p m e n t . 2 0 0 6 ' , ' 2 0 ( 2 3 ) ' , 3 2 1 5 , ' 3 1 . 6 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 p e n n i n g s s ' , ' a l l a n j ' , ' d a v e y c s . d n a m e t h y l a t i o n ' , ' n u c l e o s o m e f o r m a t i o n a n d p o s i t i o n i n g . b r i e f i n g s i n f u n c t i o n a l g e n o m i c s & ' , ' p r o t e o m i c s . 2 0 0 5 ' , ' 3 ( 4 ) ' , 3 5 1 , ' 6 1 . 6 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 j o n e s p a ' , ' b a y l i n s b . t h e e p i g e n o m i c s o f c a n c e r . c e l l . 2 0 0 7 ' , ' 1 2 8 ( 4 ) ' , 6 8 3 , ' 9 2 . 6 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s t e a r n s v ' , ' z h o u q ' , ' d a v i d s o n n e . e p i g e n e t i c r e g u l a t i o n a s a n e w t a r g e t f o r b r e a s t c a n c e r t h e r a p y . c a n c e r i n v e s t i g a t i o n . 2 0 0 7 ' , ' 2 5 ( 8 ) ' , ' 6 5 9 . 6 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 c h o e m k ' , ' h o n g c p ' , ' p a r k j ' , ' s e o s h ' , ' r o h t y . f u n c t i o n a l e l e m e n t s d e m a r c a t e d b y h i s t o n e m o d i f i c a t i o n s i n b r e a s t c a n c e r c e l l s . b i o c h e m i c a l a n d b i o p h y s i c a l r e s e a r c h c o m m u n i c a t i o n s . 2 0 1 2 . 6 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s t r a t m a n n a ' , ' h a e n d l e r b . h i s t o n e d e m e t h y l a t i o n a n d s t e r o i d r e c e p t o r f u n c t i o n i n c a n c e r . m o l e c u l a r a n d c e l l u l a r e n d o c r i n o l o g y . 2 0 1 1 . 6 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 h u n g k e ' , ' y u k h . p r o t e o m i c a p p r o a c h e s t o c a n c e r b i o m a r k e r s . g a s t r o e n t e r o l o g y . 2 0 1 0 ' , ' 1 3 8 ( 1 ) ' , ' 4 6 . 7 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s r i v a s t a v a s ' , ' s r i v a s t a v a r g . p r o t e o m i c s i n t h e f o r e f r o n t o f c a n c e r b i o m a r k e r d i s c o v e r y . j o u r n a l o f p r o t e o m e r e s e a r c h . 2 0 0 5 ' , ' 4 ( 4 ) ' , 1 0 9 8 , ' 1 0 3 . 7 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 g i l l e t t e m a ' , ' m a n i d ' , ' c a r r s a . p l a c e o f p a t t e r n i n p r o t e o m i c b i o m a r k e r d i s c o v e r y . j o u r n a l o f p r o t e o m e r e s e a r c h . 2 0 0 5 ' , ' 4 ( 4 ) ' , 1 1 4 3 , ' 5 4 . 7 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 b a s e l g a j . t r e a t m e n t o f h e r 2 ' , ' o v e r e x p r e s s i n g b r e a s t c a n c e r . a n n a l s o f o n c o l o g y . 2 0 1 0 ' , ' 2 1 ( s u p p l 7 ) ' , ' v i i 3 6 ' , ' v i i 4 0 . 7 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l e p p ä s ' , ' s a a r t o t ' , ' v e h m a n e n l ' , ' b l o m q v i s t c ' , ' e l o m a a i . a h i g h s e r u m m a t r i x m e t a l l o p r o t e i n a s e ' , ' 2 l e v e l i s a s s o c i a t e d w i t h a n a d v e r s e p r o g n o s i s i n n o d e ' , ' p o s i t i v e b r e a s t c a r c i n o m a . c l i n i c a l c a n c e r r e s e a r c h . 2 0 0 4 ' , ' 1 0 ( 3 ) ' , 1 0 5 7 , ' 6 3 . 7 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 e l y a z i d i ' , ' b e l k o u r a i ' , ' a d r i a e n s s e n s e ' , ' v e r c o u t t e r ' , ' e d o u a r t a ' , ' l e m o i n e j ' , ' n u r c o m b e v ' , ' h o n d e r m a r c k h . p r o t e o m i c s o f b r e a s t c a n c e r ' , ' o u t c o m e s a n d p r o s p e c t s . t e c h n o l o g y i n c a n c e r r e s e a r c h & ' , ' t r e a t m e n t . 2 0 0 2 ' , ' 1 ( 4 ) ' , ' 2 8 7 . 7 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 q i n x j ' , ' l i n g b x . p r o t e o m i c s t u d i e s i n b r e a s t c a n c e r ( r e v i e w ) . o n c o l o g y l e t t e r s . 2 0 1 2 ' , ' 3 ( 4 ) ' , ' 7 3 5 . 7 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m o r e i r a j m a ' , ' o h l s s o n g ' , ' r a n k f e ' , ' c e l i s j e . d o w n ' , ' r e g u l a t i o n o f t h e t u m o r s u p p r e s s o r p r o t e i n 1 4 ' , 3 , ' 3 σ i s a s p o r a d i c e v e n t i n c a n c e r o f t h e b r e a s t . m o l e c u l a r & ' , ' c e l l u l a r p r o t e o m i c s . 2 0 0 5 ' , ' 4 ( 4 ) ' , 5 5 5 , ' 6 9 . 7 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 z u r i t a m ' , ' l a r a p ' , ' d e l m o r a l r ' , ' t o r r e s b ' , ' l i n a r e s ' , ' f e r n á n d e z j ' , ' a r r a b a l s ' , ' e t a l . h y p e r m e t h y l a t e d 1 4 ' , 3 , 3 , ' σ a n d e s r 1 g e n e p r o m o t e r s i n s e r u m a s c a n d i d a t e b i o m a r k e r s f o r t h e d i a g n o s i s a n d t r e a t m e n t e f f i c a c y o f b r e a s t c a n c e r m e t a s t a s i s . b m c c a n c e r . 2 0 1 0 ' , ' 1 0 ( 1 ) ' , ' 2 1 7 . 7 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s c h u l t z j ' , ' i b r a h i m s m ' , ' v e r a j ' , ' k u n z m . 1 4 ' , 3 , ' 3 σ g e n e s i l e n c i n g d u r i n g m e l a n o m a p r o g r e s s i o n a n d i t s r o l e i n c e l l c y c l e c o n t r o l a n d c e l l u l a r s e n e s c e n c e . m o l e c u l a r c a n c e r . 2 0 0 9 ' , ' 8 ( 1 ) ' , ' 5 3 . 7 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a t h e l i n c ' , ' c r o m e r a ' , ' w e n d l i n g c ' , ' t o m a s e t t o c ' , ' r i o m c . s e r u m b i o m a r k e r s f o r d e t e c t i o n o f b r e a s t c a n c e r s ' , ' a p r o s p e c t i v e s t u d y . b r e a s t c a n c e r r e s e a r c h a n d t r e a t m e n t . 2 0 0 6 ' , ' 9 6 ( 1 ) ' , 8 3 , ' 9 0 . 8 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s a n d e r s m e ' , ' d i a s e c ' , ' x u b j ' , ' m o b l e y j a ' , ' b i l l h e i m e r d ' , ' r o d e r h ' , ' e t a l . d i f f e r e n t i a t i n g p r o t e o m i c b i o m a r k e r s i n b r e a s t c a n c e r b y l a s e r c a p t u r e m i c r o d i s s e c t i o n a n d m a l d i m s . j o u r n a l o f p r o t e o m e r e s e a r c h . 2 0 0 8 ' , ' 7 ( 4 ) ' , 1 5 0 0 , ' 7 . 8 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 b h a r g a v a r ' , ' b e r i w a l s ' , ' m c m a n u s k ' , ' d a b b s d j . c k 5 i s m o r e s e n s i t i v e t h a n c k 5 / 6 i n i d e n t i f y i n g t h e b a s a l ' , ' l i k e p h e n o t y p e o f b r e a s t c a r c i n o m a . a m e r i c a n j o u r n a l o f c l i n i c a l p a t h o l o g y . 2 0 0 8 ' , ' 1 3 0 ( 5 ) ' , 7 2 4 , ' 3 0 . 8 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 w a l i g ó r s k a ' , ' s t a c h u r a j ' , ' j a n k o w s k a a ' , ' w a ś k o r ' , ' l i e b e r t w ' , ' b i c z y s k o m ' , ' c z a r n y w o j t e k a ' , ' e t a l . s u r v i v i n ' , ' p r o g n o s t i c t u m o r b i o m a r k e r i n h u m a n n e o p l a s m s ' , ' r e v i e w . g i n e k o l o g i a p o l s k a . 2 0 1 2 ' , ' 8 3 ( 7 ) ' , ' 5 3 7 . 8 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l i u y ' , ' z h a o j ' , ' z h a n g p y ' , ' z h a n g y ' , ' s u n s y ' , ' y u s y ' , ' e t a l . m i c r o r n a ' , ' 1 0 b t a r g e t s e ' , ' c a d h e r i n a n d m o d u l a t e s b r e a s t c a n c e r m e t a s t a s i s . m e d i c a l s c i e n c e m o n i t o r ' , ' i n t e r n a t i o n a l m e d i c a l j o u r n a l o f e x p e r i m e n t a l a n d c l i n i c a l r e s e a r c h . 2 0 1 2 ' , ' 1 8 ( 8 ) ' , ' b r 2 9 9 . 8 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l i j ' , ' z h a n g z ' , ' r o s e n z w e i g j ' , ' w a n g y y ' , ' c h a n d w . p r o t e o m i c s a n d b i o i n f o r m a t i c s a p p r o a c h e s f o r i d e n t i f i c a t i o n o f s e r u m b i o m a r k e r s t o d e t e c t b r e a s t c a n c e r . c l i n i c a l c h e m i s t r y . 2 0 0 2 ' , ' 4 8 ( 8 ) ' , 1 2 9 6 , ' 3 0 4 . 8 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l i m y p . m i n i n g t h e t u m o r p h o s p h o p r o t e o m e f o r c a n c e r m a r k e r s . c l i n i c a l c a n c e r r e s e a r c h . 2 0 0 5 ' , ' 1 1 ( 9 ) ' , 3 1 6 3 , ' 9 . 8 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 g a m a g e d a r a s ' , ' m a y . b i o m a r k e r a n a l y s i s f o r p r o s t a t e c a n c e r d i a g n o s i s u s i n g l c ' , ' m s a n d c e ' , ' m s . b i o a n a l y s i s . 2 0 1 1 ' , ' 3 ( 1 8 ) ' , 2 1 2 9 , ' 4 2 . 8 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 w h e l a n s a ' , ' l u m ' , ' h e j ' , ' y a n w ' , ' s a x t o n r e ' , ' f a u l l k f ' , ' e t a l . m a s s s p e c t r o m e t r y ( l c ' , ' m s / m s ) s i t e ' , ' m a p p i n g o f n ' , ' g l y c o s y l a t e d m e m b r a n e p r o t e i n s f o r b r e a s t c a n c e r b i o m a r k e r s . j p r o t e o m e r e s . 2 0 0 9 ' , ' 8 ( 8 ) ' , 4 1 5 1 , ' 6 0 . 8 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s o n g j ' , ' p a t e l m ' , ' r o s e n z w e i g c n ' , ' c h a n ' , ' l i y ' , ' s o k o l l l j ' , ' f u n g e t ' , ' e t a l . q u a n t i f i c a t i o n o f f r a g m e n t s o f h u m a n s e r u m i n t e r ' , ' a l p h a ' , ' t r y p s i n i n h i b i t o r h e a v y c h a i n 4 b y a s u r f a c e ' , ' e n h a n c e d l a s e r d e s o r p t i o n / i o n i z a t i o n ' , ' b a s e d i m m u n o a s s a y . c l i n c h e m . 2 0 0 6 ' , ' 5 2 ( 6 ) ' , 1 0 4 5 , ' 5 3 . 8 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 g r a v e s p r ' , ' h a y s t e a d t a j . m o l e c u l a r b i o l o g i s t & ' , ' # 0 3 9 ' , ' s g u i d e t o p r o t e o m i c s . m i c r o b i o l o g y a n d m o l e c u l a r b i o l o g y r e v i e w s . 2 0 0 2 ' , ' 6 6 ( 1 ) ' , 3 9 , ' 6 3 . 9 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k a n g u b ' , ' a h n y ' , ' l e e j w ' , ' k i m y h ' , ' k i m j ' , ' y u m h ' , ' e t a l . d i f f e r e n t i a l p r o f i l i n g o f b r e a s t c a n c e r p l a s m a p r o t e o m e b y i s o t o p e ' , ' c o d e d a f f i n i t y t a g g i n g m e t h o d r e v e a l s b i o t i n i d a s e a s a b r e a s t c a n c e r b i o m a r k e r . b m c c a n c e r . 2 0 1 0 ' , 1 0 , ' 1 1 4 . 9 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 u e d a m ' , ' m i s u m i y ' , ' m i z u g u c h i m ' , ' n a k a m u r a m ' , ' y a m a s h i t a t ' , ' s e k i j i m a y ' , ' e t a l . s e l d i ' , ' t o f m a s s s p e c t r o m e t r y e v a l u a t i o n o f v a r i a n t t r a n s t h y r e t i n s f o r d i a g n o s i s a n d p a t h o g e n e s i s o f f a m i l i a l a m y l o i d o t i c p o l y n e u r o p a t h y . c l i n i c a l c h e m i s t r y . 2 0 0 9 ' , ' 5 5 ( 6 ) ' , 1 2 2 3 , ' 7 . 9 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l e b r e c h t a ' , ' b o e h m d ' , ' s c h m i d t m ' , ' k o e l b l h ' , ' g r u s f h . s u r f a c e ' , ' e n h a n c e d l a s e r d e s o r p t i o n / i o n i s a t i o n t i m e ' , ' o f ' , ' f l i g h t m a s s s p e c t r o m e t r y t o d e t e c t b r e a s t c a n c e r m a r k e r s i n t e a r s a n d s e r u m . c a n c e r g e n o m i c s p r o t e o m i c s . 2 0 0 9 ' , ' 6 ( 2 ) ' , 7 5 , ' 8 3 . ' ]

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023